Synchronous multiple primary malignant neoplasms: a case report of malignant peritoneal mesothelioma and neuroendocrine rectal tumor

We report a rare case of synchronous malignant peritoneal mesothelioma the biphasic histological type and neuroendocrine tumor (NET) rectum without history asbestos exposure.
 During 2 years since manifestation disease patient underwent 3 cytoreductive surgeries (CRS): removal sigmoid mesentery, resection rectosigmoid junction completeness cytoreduction (CC) 0 (2017), omentectomy partial parietal peritonectomy CC-0 atypical S2, S4, S5 liver, abdominal with left-sided en-block hemicolectomy, peritonectomy, argon-plasma coagulation foci on mesentery small intestine CC-2 (2018) Transanal Minimally Invasive Surgery-removal rectal (2017). The hyperthermic intraperitoneal chemotherapy (HIPEC) twice (during 2nd 3rd CRS). Different regimens HIPEC were performed: cisplatin + doxorubicin (2017) metamycin C (2018). received 4 courses adjuvant plus pemetrexed in 2017 gemcitabine carboplatin bevacizumab 2018.
 survived 21 months after detection died last surgery from progression disease.
 Histological subtype MPMP remains important factor prognosis even early stages though had most aggressive variant special treatment. invasive treatment tactics NET demonstrated clinical effectiveness.